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RBC

20S proteasomes secreted by the malaria parasite promote its growth

February 23, 2021 - 13:33 -- Open Access
Author(s): 
Dekel E, Yaffe D, Regev-Rudzki N, et al.
Reference: 
Nat Commun. 2021 Feb 19;12(1):1172

Mature red blood cells (RBCs) lack internal organelles and canonical defense mechanisms, making them both a fascinating host cell, in general, and an intriguing choice for the deadly malaria parasite Plasmodium falciparum (Pf), in particular. Pf, while growing inside its natural host, the human RBC, secretes multipurpose extracellular vesicles (EVs), yet their influence on this essential host cell remains unknown.

NOT Open Access | Hemozoin is a potential threat in cerebral malaria pathology through the induction of RBC-EC cytoadherence

February 23, 2021 - 13:18 -- NOT Open Access
Author(s): 
Mehra A, Balaji SN, Trivedi V
Reference: 
Acta Trop. 2021 Feb 18:105867

Cerebral malaria is an outcome of multifaceted and complicated condition. Cytoadherence is one critical factor in cerebral malaria pathology as high order cytoadherence complexes result in vascular congestion and cell apoptosis. Morphological abnormalities in uninfected RBCs can be a contributing factor to aggravate cytoadherence. Malaria pigment hemozoin is a potential bioactive molecule and the role of this pigment in cerebral malaria pathology is not completely understood. To understand this, primarily we investigated the impact of hemozoin pigment on uninfected RBCs.

NOT Open Access | A review on Development and Characterization of a Cost-Effective Targeted Quality-Driven Antimalarial Product with an Emphasis on Phytosomes

February 20, 2021 - 08:47 -- NOT Open Access
Author(s): 
Bhargav E, Padmanabha Reddy Y, Koteshwara KB
Reference: 
Curr Drug Targets. 2021 Feb 4

Malaria, a protozoan disease led to numerous deaths and several new million cases raised due to the development of resistance as per the WHO malaria report 2019. This can be overcome by the development of an effective targeted plant-based delivery system through phytosomes that are effective in permeation and bioavailability to treat infected RBCs (parasitic cells).

NOT Open Access | The spleen: "epicenter" in malaria infection and immunity

January 20, 2021 - 07:17 -- NOT Open Access
Author(s): 
Ghosh D, Stumhofer JS
Reference: 
J Leukoc Biol. 2021 Jan 19

The spleen is a complex secondary lymphoid organ that plays a crucial role in controlling blood-stage infection with Plasmodium parasites. It is tasked with sensing and removing parasitized RBCs, erythropoiesis, the activation and differentiation of adaptive immune cells, and the development of protective immunity, all in the face of an intense inflammatory environment.

NOT Open Access | Epstein-Barr virus infection modulates blood-brain barrier cells and its co-infection with Plasmodium falciparum induces RBC adhesion

December 30, 2020 - 13:36 -- NOT Open Access
Author(s): 
Indari O, Chandramohanadas R, Jha HC
Reference: 
Pathog Dis. 2020 Dec 23:ftaa080

Plasmodium (P.) falciparum infection mediated Epstein-Barr virus (EBV) reactivation is well established in malaria-endemic countries. We hypothesize that, during malaria onset, the reactivated EBV can infect human brain microvascular endothelial cells (HBECs). This may cause severe cerebral manifestations. We infected HBECs with EBV in vitro. The subsequent gene expression pattern of EBV, inflammatory and endothelial markers was analysed using qRT-PCR.

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