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dihydroorotate dehydrogenas

Not Open Access | Atypical molecular basis for drug resistance to mitochondrial function inhibitors in Plasmodium falciparum

December 29, 2020 - 15:19 -- NOT Open Access
Author(s): 
Painter HJ, Morrisey JM, Mather MW, Orchard LM, Luck C, Smilkstein MJ, Riscoe MK, Vaidya AB, Llinás M
Reference: 
Antimicrob Agents Chemother. 2020 Dec 23:AAC.02143-20

The continued emergence of drug-resistant Plasmodium falciparum parasites hinders global attempts to eradicate malaria, emphasizing the need to identify new antimalarial drugs. Attractive targets for chemotherapeutic intervention are the cytochrome (cyt) bc1 complex, which is an essential component of the mitochondrial electron transport chain (mtETC) necessary for ubiquinone recycling and mitochondrially localized dihydroorotate dehydrogenase (DHODH) critical for de novo pyrimidine synthesis.

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