IgG acquisition against PfEMP1 PF11_0521 domain cassette DC13, DBLbeta3_D4 domain, and peptides located within these constructs in children with cerebral malaria
The Plasmodium falciparum erythrocyte-membrane-protein-1 (PF3D7_1150400/PF11_0521) contains both domain cassette DC13 and DBLβ3 domain binding to EPCR and ICAM-1 receptors, respectively. This type of PfEMP1 proteins with dual binding specificity mediate specific interactions with brain micro-vessels endothelium leading to the development of cerebral malaria (CM).