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IgG acquisition against PfEMP1 PF11_0521 domain cassette DC13, DBLbeta3_D4 domain, and peptides located within these constructs in children with cerebral malaria

February 15, 2021 - 15:18 -- Open Access
Cyril B, Visitdesotrakul P, Tahar R, et al.
Sci Rep. 2021 Feb 11;11(1):3680

The Plasmodium falciparum erythrocyte-membrane-protein-1 (PF3D7_1150400/PF11_0521) contains both domain cassette DC13 and DBLβ3 domain binding to EPCR and ICAM-1 receptors, respectively. This type of PfEMP1 proteins with dual binding specificity mediate specific interactions with brain micro-vessels endothelium leading to the development of cerebral malaria (CM).

Two 20-Residue-Long Peptides Derived from Plasmodium vivax Merozoite Surface Protein 10 EGF-Like Domains Are Involved in Binding to Human Reticulocytes

February 11, 2021 - 09:25 -- Open Access
Ricaurte-Contreras LA, Lovera A, Moreno-Pérez DA, Bohórquez MD, Suárez CF, Gutiérrez-Vásquez E, Cuy-Chaparro L, Garzón-Ospina D, Patarroyo MA
Int J Mol Sci. 2021 Feb 5;22(4):1609

Plasmodium parasites' invasion of their target cells is a complex, multi-step process involving many protein-protein interactions. Little is known about how complex the interaction with target cells is in Plasmodium vivax and few surface molecules related to reticulocytes' adhesion have been described to date. Natural selection, functional and structural analysis were carried out on the previously described vaccine candidate P. vivax merozoite surface protein 10 (PvMSP10) for evaluating its role during initial contact with target cells.

The molecular basis for peptide-based antimalarial vaccine development targeting erythrocyte invasion by P. falciparum

December 15, 2020 - 14:15 -- Open Access
Aza-Conde J, Reyes C, Suárez CF, Patarroyo MA, Patarroyo ME
Biochem Biophys Res Commun. 2020 Dec 10;534:86-93

This work describes a methodology for developing a minimal, subunit-based, multi-epitope, multi-stage, chemically-synthesised, anti-Plasmodium falciparum malaria vaccine. Some modified high activity binding peptides (mHABPs) derived from functionally relevant P. falciparum MSP, RH5 and AMA-1 conserved amino acid regions (cHABPs) for parasite binding to and invasion of red blood cells (RBC) were selected.

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