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haem metabolism

Disruption of Plasmodium falciparum histidine-rich protein 2 may affect haem metabolism in the blood stage

December 15, 2020 - 16:03 -- Open Access
Author(s): 
Yang Y, Tang T, Feng B, Li S, Hou N, Ma X, Jiang L, Xin X, Chen Q
Reference: 
Parasit Vectors. 2020 Dec 9;13(1):611

Haem is a key metabolic factor in the life cycle of the malaria parasite. In the blood stage, the parasite acquires host haemoglobin to generate amino acids for protein synthesis and the by-product haem for metabolic use. The malaria parasite can also synthesize haem de novo on its own. Plasmodium falciparum-specific histidine-rich protein 2 (PfHRP2) has a haem-binding site to mediate the formation of haemozoin, a biocrystallized form of haem aggregates. Notably, the gene regulates the mechanism of haemoglobin-derived haem metabolism and the de novo haem biosynthetic pathway in the Pfhrp2-disrupted parasite line during the intraerythrocytic stages.

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