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P450 enzyme

NOT Open Access | Metabolism and Interactions of Chloroquine and Hydroxychloroquine with Human Cytochrome P450 Enzymes and Drug Transporters

December 10, 2020 - 09:59 -- NOT Open Access
Author(s): 
Rendic SP, Guengerich FP
Reference: 
Curr Drug Metab. 2020 Dec 8

In clinical practice chloroquine and hydroxychloroquine are often co-administered with other drugs in the treatment of malaria, chronic inflammatory diseases, and COVID-19. Therefore, their metabolic properties and the effects on activity of cytochrome P450 (P450, CYP) enzymes and drug transporters should be considered into when developing the most efficient treatments for patients.

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