The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10907 malaria professionals are enjoying the free benefits of MalariaWorld today

cystatins

NOT Open Access | Cyclic peptide engineered from phytocystatin inhibitory hairpin loop as an effective modulator of falcipains and potent antimalarial

December 10, 2020 - 09:50 -- NOT Open Access
Author(s): 
Mishra M, Singh V, Tellis MB, Joshi RS, Pandey KC, Singh S
Reference: 
J Biomol Struct Dyn. 2020 Dec 9:1-13

Cystatins are classical competitive inhibitors of C1 family cysteine proteases (papain family). Phytocystatin superfamily shares high sequence homology and typical tertiary structure with conserved glutamine-valine-glycine (Q-X-V-X-G) loop blocking the active site of C1 proteases. Here, we develop a cysteine-bounded cyclic peptide (CYS-cIHL) and linear peptide (CYS-IHL), using the conserved inhibitory hairpin loop amino acid sequence.

Subscribe to RSS - cystatins