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hybrids

NOT Open Access | The antimalarial activity of indole alkaloids and hybrids

August 17, 2020 - 13:10 -- NOT Open Access
Author(s): 
Li JY, Sun XF, Li JJ, Yu F, Zhang Y, Huang XJ, Jiang FX
Reference: 
Arch Pharm (Weinheim). 2020 Aug 12:e2000131

Malaria, caused by the genus Plasmodium, remains a global public health concern. It is estimated by the World Health Organization that over 40% of the world's population lives in areas at risk for malarial transmission, and around half a million people succumb to this infectious disease annually, which is related to the rapid spread of drug-resistant parasite strains.

Current scenario of ferrocene-containing hybrids for antimalarial activity

November 8, 2019 - 17:02 -- Open Access
Author(s): 
Xiao J, Sun Z, Kong F, Gao F.
Reference: 
Eur J Med Chem. 2019 Oct 17; 185:111791

Hybrid molecules have the potential to enhance the efficacy against both drug-sensitive and drug-resistant organisms, and Ferroquine, a ferrocene hybrid, has demonstrated great potency in clinical trials against both drug-sensitive and drug-resistant malaria. Accordingly, hybridization of ferrocene with other antimalarial pharmacophores represents a promising strategy to develop novel antimalarial candidates.

Medical Condition: 
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