The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10907 malaria professionals are enjoying the free benefits of MalariaWorld today

plasmodial transketolases

Characterisation of plasmodial transketolases and identification of potential inhibitors: an in silico study

December 2, 2020 - 08:00 -- Open Access
Author(s): 
Rita Afriyie Boateng, Özlem Tastan Bishop and Thommas Mutemi Musyoka
Reference: 
Malaria Journal 2020 19:442, 30 November 2020

Plasmodial transketolase (PTKT) enzyme is one of the novel pharmacological targets being explored as potential anti-malarial drug target due to its functional role and low sequence identity to the human enzyme. Despite this, features contributing to such have not been exploited for anti-malarial drug design. Additionally, there are no anti-malarial drugs targeting PTKTs whereas the broad activity of these inhibitors against PTKTs from other Plasmodium spp. is yet to be reported. This study characterises different PTKTs [Plasmodium falciparum (PfTKT), Plasmodium vivax (PvTKT), Plasmodium ovale (PoTKT), Plasmodium malariae (PmTKT) and Plasmodium knowlesi (PkTKT) and the human homolog (HsTKT)] to identify key sequence and structural based differences as well as the identification of selective potential inhibitors against PTKTs.

Subscribe to RSS - plasmodial transketolases