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NOT Open Access | Manipulating niche composition limits damage to haematopoietic stem cells during Plasmodium infection

November 25, 2020 - 13:16 -- NOT Open Access
Author(s): 
Haltalli MLR, Watcham S, Lo Celso C, et al.
Reference: 
Nat Cell Biol. 2020 Nov 23

Severe infections are a major stress on haematopoiesis, where the consequences for haematopoietic stem cells (HSCs) have only recently started to emerge. HSC function critically depends on the integrity of complex bone marrow (BM) niches; however, what role the BM microenvironment plays in mediating the effects of infection on HSCs remains an open question.

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