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antiplasmodial hits

Not Open Access | 4,9-diaminoacridines and 4-aminoacridines as dual-stage antiplasmodial hits

November 24, 2020 - 13:33 -- NOT Open Access
Fonte M, Tassi N, Fontinha D, Bouzón-Arnáiz I, Ferraz R, Araújo MJ, Fernàndez-Busquets X, Prudêncio M, Gomes P, Teixeira C
ChemMedChem. 2020 Nov 20

Multi-stage drugs have been prioritized in antimalarial drug discovery, as targeting more than one process in the Plasmodium life cycle is likely to increase efficiency, while decreasing the chances of emergence of resistance by the parasite. Herein, we disclose two novel acridine-based families of compounds that combine the structural features of primaquine and chloroquine.

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