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Mycobacterium tuberculosis

NOT Open Access | Antimicrobial evaluation of neutral and cationic iridium(III) and rhodium(III) aminoquinoline-benzimidazole hybrid complexes

November 19, 2020 - 13:41 -- NOT Open Access
Author(s): 
Baartzes N, Jordaan A, Warner DF, Combrinck J, Taylor D, Chibale K, Smith GS
Reference: 
Eur J Med Chem. 2020 Nov 15;206:112694

A series of neutral and cationic Ir(III) and Rh(III) aminoquinoline-benzimidazole hybrid complexes were synthesised and their inhibitory activities evaluated against Plasmodium falciparum and Mycobacterium tuberculosis. In general, the hybrid complexes display good activity against the chloroquine-sensitive NF54 strain of P. falciparum.

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