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NOT Open Access | An Antibody-Free Dual-Biomarker Rapid Enrichment Workflow (AnDREW) Improves the Sensitivity of Malaria Rapid Diagnostic Tests

November 19, 2020 - 13:37 -- NOT Open Access
Kantor AG, Markwalter CF, Nourani A, Wright DW
Anal Biochem. 2020 Nov 15:114020

Rapid diagnostic tests (RDTs) are critical to the success of malaria elimination campaigns. These tests are rapid, user-friendly, and field-deployable to resource-limited regions. However, RDTs demonstrate poor sensitivity because they can only tolerate a small (5 μL) volume of blood, which limits the amount of protein biomarker delivered to the test. We have developed the Antibody-free Dual-biomarker Rapid Enrichment Workflow (AnDREW) for purifying histidine-rich protein 2 (HRP2) and Plasmodium lactate dehydrogenase (PLDH) from large volume (150 μL) blood samples.

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