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Malaria vaccine roller coaster

October 16, 2021 - 20:15 -- Open Access
Nkumama IN, Osier FHA
Nat Microbiol. 2021 Oct 11

Malaria vaccine development has been characterised by excitement and disappointment in equal measure. Candidates that have shown promise in pre-clinical animal models and phase 1/2 clinical trials in volunteers who are malaria naive typically do not make the grade when tested in malaria-endemic populations.

NOT Open Access | Two chemoattenuated PfSPZ malaria vaccines induce sterile hepatic immunity

July 7, 2021 - 15:08 -- NOT Open Access
Mwakingwe-Omari A, Healy SA, Duffy PE, et al.
Nature. 2021 Jun 30

The global decline in malaria has stalled1, emphasizing the need for vaccines that induce durable sterilizing immunity. Here we optimized regimens for chemoprophylaxis vaccination (CVac), for which aseptic, purified, cryopreserved, infectious Plasmodium falciparum sporozoites (PfSPZ) were inoculated under prophylactic cover with pyrimethamine (PYR) (Sanaria PfSPZ-CVac(PYR)) or chloroquine (CQ) (PfSPZ-CVac(CQ))-which kill liver-stage and blood-stage parasites, respectively-and we assessed vaccine efficacy against homologous (that is, the same strain as the vaccine) and heterologous (a different strain) controlled human malaria infection (CHMI) three months after immunization ( , NCT02511054 and NCT03083847).

Immunogenicity and Protective Efficacy of Radiation-Attenuated and Chemo-Attenuated PfSPZ Vaccines in Equatoguinean Adults

November 19, 2020 - 12:58 -- Open Access
Jongo SA, Urbano V, Hoffman SL, et al.
Am J Trop Med Hyg. 2020 Nov 16

Plasmodium falciparum sporozoite (PfSPZ) Vaccine (radiation-attenuated, aseptic, purified, cryopreserved PfSPZ) and PfSPZ-CVac (infectious, aseptic, purified, cryopreserved PfSPZ administered to subjects taking weekly chloroquine chemoprophylaxis) have shown vaccine efficacies (VEs) of 100% against homologous controlled human malaria infection (CHMI) in nonimmune adults. Plasmodium falciparum sporozoite-CVac has never been assessed against CHMI in African vaccinees.

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