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cerebrovascular endothelium

PfEMP1 A-Type ICAM-1-Binding Domains Are Not Associated with Cerebral Malaria in Beninese Children

November 19, 2020 - 13:47 -- Open Access
Joste V, Guillochon E, Fraering J, Vianou B, Watier L, Jafari-Guemouri S, Cot M, Houzé S, Aubouy A, Faucher JF, Argy N, Bertin GI
mBio. 2020 Nov 17;11(6):e02103-20

PfEMP1 is the major antigen involved in Plasmodium falciparum-infected erythrocyte sequestration in cerebrovascular endothelium. While some PfEMP1 domains have been associated with clinical phenotypes of malaria, formal associations between the expression of a specific domain and the adhesion properties of clinical isolates are limited. In this context, 73 cerebral malaria (CM) and 98 uncomplicated malaria (UM) Beninese children were recruited. We attempted to correlate the cytoadherence phenotype of Plasmodium falciparum isolates with the clinical presentation and the expression of specific PfEMP1 domains.

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