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hippocampal neurogenesis

A history of juvenile mild malaria exacerbates chronic stress-evoked anxiety-like behavior, neuroinflammation, and decline of adult hippocampal neurogenesis in mice

November 19, 2020 - 13:43 -- Open Access
Guha SK, Sarkar I, Patgaonkar M, Banerjee S, Mukhopadhyay S, Sharma S, Pathak S, Vaidya VA
J Neuroimmunol. 2020 Nov 15;348:577363

Children residing in high malaria transmission regions are particularly susceptible to malaria. This early-life window is also a critical period for development and maturation of the nervous system, and inflammatory insults during this period may evoke a persistent increase in vulnerability for psychopathology. We employed a two-hit model of juvenile mild malaria and a two-week chronic unpredictable mild stress (CUMS) regime, commencing 60 days post-parasite clearance, to assess whether a history of juvenile infection predisposed the mice towards mood-related behavioral alterations and neurocognitive deficits.

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