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inhibitory KIR ligand

NOT Open Access | Inhibitory KIR ligands are associated with higher P. falciparum parasite prevalence

November 10, 2020 - 14:36 -- NOT Open Access
Digitale JC, Callaway PC, Feeney ME, et al.
J Infect Dis. 2020 Nov 9:jiaa698

Killer cell immunoglobulin-like receptors (KIR) and their HLA ligands influence the outcome of many infectious diseases. We analyzed the relationship of compound KIR-HLA genotypes with risk of Plasmodium falciparum infection in a longitudinal cohort of 890 Ugandan individuals. We found that presence of HLA-C2 and HLA-Bw4, ligands for inhibitory KIR2DL1 and KIR3DL1, respectively, increased the likelihood of P. falciparum parasitemia in an additive manner.

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