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neuronal damage

NOT Open Access | Retinopathy-Positive Cerebral Malaria Is Associated With Greater Inflammation, Blood-Brain Barrier Breakdown, and Neuronal Damage Than Retinopathy-Negative Cerebral Malaria

November 11, 2020 - 14:34 -- NOT Open Access
Author(s): 
Villaverde C, Namazzi R, Shabani E, Park GS, Datta D, Hanisch B, Opoka RO, John CC
Reference: 
J Pediatric Infect Dis Soc. 2020 Nov 10;9(5):580-586

Our prior study findings suggest that Plasmodium falciparum is the cause of disease in both malaria retinopathy-positive (RP) and most retinopathy-negative (RN) cerebral malaria (CM), and that absence of retinopathy and decreased disease severity in RN CM may be due to shorter duration of illness, lower parasite biomass, and decreased var gene expression in RN compared to RP CM. In the present study, we assessed the pathophysiology of RP and RN CM.

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