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metabolic resistance

CYP6P9-Driven Signatures of Selective Sweep of Metabolic Resistance to Pyrethroids in the Malaria Vector Anopheles funestus Reveal Contemporary Barriers to Gene Flow

November 10, 2020 - 15:05 -- Open Access
Author(s): 
Djuicy DD, Hearn J, Tchouakui M, Wondji MJ, Irving H, Okumu FO, Wondji CS
Reference: 
Genes (Basel). 2020 Nov 5;11(11):E1314

Pyrethroid resistance in major malaria vectors such as Anopheles funestus threatens malaria control efforts in Africa. Cytochrome P450-mediated metabolic resistance is best understood for CYP6P9 genes in southern Africa in An. funestus. However, we do not know if this resistance mechanism is spreading across Africa and how it relates to broader patterns of gene flow across the continent.

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