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mitochondrial dysfunction

NOT Open Access | Antimalarial properties and preventive effects on mitochondrial dysfunction by extract and fractions of Phyllanthus amarus (Schum. and Thonn) in Plasmodium berghei-infected mice

November 10, 2020 - 14:30 -- NOT Open Access
Olanlokun JO, Babarinde CO, Olorunsogo OO
J Basic Clin Physiol Pharmacol. 2020 Nov 6, 20200046, eISSN 2191-0286, ISSN 0792-6855

Broad spectrum antimalarial drugs without deleterious effects on mitochondria are scarce. It is in this regard that we investigated the potency of methanol extract and solvent fractions of Phyllanthus amarus on chloroquine-susceptible and resistant strains of Plasmodium berghei, toxicity and its consequential effects on mitochondrial permeability transition (mPT) pore opening.

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