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Plasmodium translocon component EXP2 facilitates hepatocyte invasion

November 10, 2020 - 13:50 -- Open Access
Mello-Vieira J, Enguita FJ, de Koning-Ward TF, Zuzarte-Luís V, Mota MM
Nat Commun. 2020 Nov 6;11(1):5654

Plasmodium parasites possess a translocon that exports parasite proteins into the infected erythrocyte. Although the translocon components are also expressed during the mosquito and liver stage of infection, their function remains unexplored. Here, using a combination of genetic and chemical assays, we show that the translocon component Exported Protein 2 (EXP2) is critical for invasion of hepatocytes.

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