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Messenger RNA expressing PfCSP induces functional, protective immune responses against malaria in mice

June 22, 2021 - 15:09 -- Open Access
Mallory KL, Taylor JA, Angov E, et al.
NPJ Vaccines. 2021 Jun 18;6(1):84

Human malaria affects the vast majority of the world's population with the Plasmodium falciparum species causing the highest rates of morbidity and mortality. With no licensed vaccine and leading candidates achieving suboptimal protection in the field, the need for an effective immunoprophylactic option continues to motivate the malaria research community to explore alternative technologies. Recent advances in the mRNA discipline have elevated the long-neglected platform to the forefront of infectious disease research.

A high-affinity antibody against the CSP N-terminal domain lacks Plasmodium falciparum inhibitory activity

November 4, 2020 - 15:59 -- Open Access
Thai E, Costa G, Levashina EA, et al.
J Exp Med. 2020 Nov 2;217(11):e20200061

Malaria is a global health concern, and research efforts are ongoing to develop a superior vaccine to RTS,S/AS01. To guide immunogen design, we seek a comprehensive understanding of the protective humoral response against Plasmodium falciparum (Pf) circumsporozoite protein (PfCSP).

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