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No evidence that chloroquine or hydroxychloroquine induce hemolysis in G6PD deficiency

November 4, 2020 - 16:10 -- Open Access
Schilling WHK, Bancone G, White NJ
Blood Cells Mol Dis. 2020 Nov;85:102484

Hydroxychloroquine and chloroquine have come under intense scrutiny over the past six months as they have been proposed as treatments for COVID-19. It is widely quoted and stated that the 4-aminoquinolines chloroquine and hydroxychloroquine cause oxidant hemolysis in glucose-6-phosphate dehydrogenase (G6PD) deficiency, yet there is no convincing evidence for this claim, and there is substantial evidence against it. X-linked G6PD deficiency is the most common human enzymopathy.

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