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NOT Open Access | Autophagy-related protein PfATG18 participates in food vacuole dynamics and autophagy-like pathway in Plasmodium falciparum

January 15, 2020 - 09:17 -- NOT Open Access
Agrawal P, Manjithaya R, Surolia N
Mol Microbiol, 2019 Dec 21.

Plasmodium falciparum has a limited repertoire of autophagy‐related genes (ATGs), and the functions of various proteins of the autophagy‐like pathway are not fully established in this protozoan parasite. Studies suggest that some of the autophagy proteins are crucial for parasite growth. PfATG18, for example, is essential for parasite replication and has a noncanonical role in apicoplast biogenesis. In this study, we demonstrate the conserved functions of PfATG18 in food vacuole (FV) dynamics and autophagy. Intriguingly, the P. falciparum FV is found to undergo fission and fusion and PfATG18 gets enriched at the interfaces of the newly generated multilobed FV during the process.

The contribution of host cell-directed vs. parasite-directed immunity to the disease and dynamics of malaria infections

November 5, 2019 - 12:47 -- Open Access
Nina Wale, Matthew J. Jones, Derek G. Sim, Andrew F. Read, and Aaron A. King
PNAS October 29, 2019 116 (44) 22386-22392

Hosts defend themselves against pathogens by mounting an immune response. Fully understanding the immune response as a driver of host disease and pathogen evolution requires a quantitative account of its impact on parasite population dynamics.

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