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covalent inhibitors

Targeted Covalent Inhibitors for the Treatment of Malaria

October 20, 2020 - 15:59 -- Open Access
Author(s): 
Kulkarni S, Urbahns K, Spangenberg T
Reference: 
ACS Infect Dis. 2020 Oct 15

Malaria is a vector-borne disease caused by protozoan parasites of the genus Plasmodium. According to the World Health Organization, it is one of the most serious infectious diseases threatening more than 3 billion people worldwide. In recent years, targeted covalent inhibitors (TCIs) have gained a lot of attention and several TCI-based drugs have been approved across different therapeutic areas.

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