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PfRH

Population genetic and biophysical evidences reveal that purifying selection shapes the genetic landscape of Plasmodium falciparum RH ligands in Chhattisgarh and West Bengal, India

October 15, 2020 - 08:19 -- Open Access
Author(s): 
Sharmistha Ghoshal, Pramita Chowdhury, Sanhita Ray, Mitashree Mitra, Sumana Datta Kanjilal, Srikanta Sen, Anjan Kr. Dasgupta and Sanghamitra Sengupta
Reference: 
Malaria Journal 2020 19:367,14 October 2020

Reticulocyte binding protein-like homologs (RHs) are currently being evaluated as anti-erythrocytic stage vaccine targets against Plasmodium falciparum malaria. Present study explores the possible evolutionary drivers shaping the genetic organization of Pfrhs in Indian parasite population. It simultaneously evaluates a putative gain-of-function variant of PfRH5, a keystone member of PfRH family.

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