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dose-dependence

Uncovering drivers of dose-dependence and individual variation in malaria infection outcomes

October 15, 2020 - 08:52 -- Open Access
Author(s): 
Kamiya T, Greischar MA, Schneider DS, Mideo N
Reference: 
PLoS Comput Biol. 2020 Oct 8;16(10):e1008211

To understand why some hosts get sicker than others from the same type of infection, it is essential to explain how key processes, such as host responses to infection and parasite growth, are influenced by various biotic and abiotic factors. In many disease systems, the initial infection dose impacts host morbidity and mortality. To explore drivers of dose-dependence and individual variation in infection outcomes, we devised a mathematical model of malaria infection that allowed host and parasite traits to be linear functions (reaction norms) of the initial dose.

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