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pfcoronin

NOT Open Access | Absence of association between polymorphisms in the pfcoronin and pfk13 genes and the presence of Plasmodium falciparum parasites after treatment with artemisinin derivatives in Senegal

October 15, 2020 - 08:36 -- NOT Open Access
Tags: 
chloroquine, sulfadoxine-pyrimethamine, pfcoronin, pfk13 genes, plasmodium falciparum, after treatment, artemisinin derivatives, artemisinin resistance, Southeast Asia, Senegal
Author(s): 
Delandre O, Daffe SM, Pradines B, et al.
Reference: 
Int J Antimicrob Agents. 2020 Oct 9:106190

Due to resistance to chloroquine and sulfadoxine-pyrimethamine, treatment for uncomplicated Plasmodium falciparum malaria switched to artemisinin-based combination therapy (ACT) in 2006 in Senegal. Several mutations in the gene coding the kelch13 helix (pfk13-propeller) were identified to be associated with in vitro and in vivo artemisinin resistance in Southeast Asia.

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