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antimalarial antibody

Antimalarial antibody repertoire defined by plasma IG proteomics and single B cell IG sequencing

October 14, 2020 - 12:35 -- Open Access
Author(s): 
Coelho CH, Nadakal ST, Duffy PE, et al.
Reference: 
JCI Insight. 2020 Oct 13:143471

Plasma antimalarial antibody can mediate anti-parasite immunity but has not previously been characterized at the molecular level. Here, we develop an innovative strategy to characterize humoral responses by integrating profiles of plasma immunoglobulins (IG) or antibodies with those expressed on B cells as part of BcR. We applied this strategy to define plasma IG and determine variable V gene usage after vaccination with the Plasmodium falciparum zygote antigen Pfs25.

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