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antimalarial chemoprevention

Transcriptome dynamics of CD4(+) T cells during malaria maps gradual transit from effector to memory

October 14, 2020 - 12:33 -- Open Access
Author(s): 
Soon MSF, Lee HJ, Haque A, et al.
Reference: 
Nat Immunol. 2020 Oct 12

The dynamics of CD4+ T cell memory development remain to be examined at genome scale. In malaria-endemic regions, antimalarial chemoprevention protects long after its cessation and associates with effects on CD4+ T cells. We applied single-cell RNA sequencing and computational modelling to track memory development during Plasmodium infection and treatment.

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