The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10649 malaria professionals are enjoying the free benefits of MalariaWorld today

multidrug-resistance

NOT Open Access | Ganoweberianones A and B, Antimalarial Lanostane Dimers from Cultivated Fruiting Bodies of the Basidiomycete Ganoderma weberianum

October 28, 2020 - 10:23 -- NOT Open Access
Author(s): 
Isaka M, Chinthanom P, Vichai V, Sommai S, Choeyklin R
Reference: 
J Nat Prod. 2020 Oct 27

Two lanostane dimers, ganoweberianones A (1) and B (2), together with seven previously undescribed lanostanes, ganoweberianic acids A-G (3-9), and three known compounds (10-12), were isolated from the artificially cultivated fruiting bodies of the basidiomycete Ganoderma weberianum.

NOT Open Access | Inhibition of PfMYST HAT activity blocks Plasmodium falciparum growth and survival

October 14, 2020 - 12:29 -- NOT Open Access
Author(s): 
Sen U, Nayak A, Khurana J, Sharma D, Gupta A
Reference: 
Antimicrob Agents Chemother. 2020 Oct 12:AAC.00953-20

One of the major barrier in the prevention & control of malaria programs worldwide is the growing emergence of multidrug-resistance in Plasmodium parasite and demands continued efforts to discover & develop effective drug molecules targeting novel proteins essential for parasite survival. In recent years, epigenetic regulators have evolved as an attractive drug target option owing to their crucial role in survival and development of Plasmodium at different stages of its life cycle.

Subscribe to RSS - multidrug-resistance