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structural polymorphisms

Whole genome sequencing of Plasmodium vivax isolates reveals frequent sequence and structural polymorphisms in erythrocyte binding genes

October 13, 2020 - 13:01 -- Open Access
Author(s): 
Ford A, Kepple D, Lo E, et al.
Reference: 
PLoS Negl Trop Dis. 2020 Oct 12;14(10):e0008234

Plasmodium vivax malaria is much less common in Africa than the rest of the world because the parasite relies primarily on the Duffy antigen/chemokine receptor (DARC) to invade human erythrocytes, and the majority of Africans are Duffy negative. Recently, there has been a dramatic increase in the reporting of P. vivax cases in Africa, with a high number of them being in Duffy negative individuals, potentially indicating P. vivax has evolved an alternative invasion mechanism that can overcome Duffy negativity.

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