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Classification of invasive bloodstream infections and Plasmodium falciparum malaria using autoantibodies as biomarkers

December 8, 2020 - 11:27 -- Open Access
Krumkamp R, Struck NS, Lorenz E, Zimmermann M, Boahen KG, Sarpong N, Owusu-Dabo E, Pak GD, Jeon HJ, Marks F, Jacobs T, May J, Eibach D
Sci Rep. 2020 Dec 3;10(1):21168

A better understanding of disease-specific biomarker profiles during acute infections could guide the development of innovative diagnostic methods to differentiate between malaria and alternative causes of fever. We investigated autoantibody (AAb) profiles in febrile children (≤ 5 years) admitted to a hospital in rural Ghana.

Rapid quantification of the malaria biomarker hemozoin by improved biocatalytically initiated precipitation atom transfer radical polymerizations

October 7, 2020 - 14:35 -- Open Access
Raccio S, Pollard J, Djuhadi A, Balog S, Pellizzoni MM, Rodriguez KJ, Rifaie-Graham O, Bruns N
Analyst. 2020 Oct 1

The fight against tropical diseases such as malaria requires the development of innovative biosensing techniques. Diagnostics must be rapid and robust to ensure prompt case management and to avoid further transmission. The malaria biomarker hemozoin can catalyze atom transfer radical polymerizations (ATRP), which we exploit in a polymerization-amplified biosensing assay for hemozoin based on the precipitation polymerization of N-isopropyl acrylamide (NIPAAm).

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