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bed net efficacy

Not Open Access | A 6.5kb intergenic structural variation enhances P450-mediated resistance to pyrethroids in malaria vectors lowering bed net efficacy

September 29, 2020 - 13:15 -- NOT Open Access
Author(s): 
Mugenzi LMJ, Menze BD, Wondji CS, et al.
Reference: 
Mol Ecol. 2020 Sep 24

Elucidating the complex evolutionary armory that mosquitoes deploy against insecticides is crucial to maintain the effectiveness of insecticide-based interventions. Here, we deciphered the role of a 6.5kb structural variation (SV) in driving cytochrome P450-mediated pyrethroid resistance in the malaria vector, Anopheles funestus. Whole-genome pooled sequencing detected an intergenic 6.5kb SV between duplicated CYP6P9a/b P450s in pyrethroid-resistant mosquitoes through a translocation event.

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