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cardiomyopathy

Pharmacological and cardiovascular perspectives on the treatment of COVID-19 with chloroquine derivatives

September 24, 2020 - 14:05 -- Open Access
Author(s): 
Zhang XL, Li ZM, Ye JT, Lu J, Ye LL, Zhang CX, Liu PQ, Duan DD
Reference: 
Acta Pharmacol Sin. 2020 Sep 23

The novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19) and an ongoing severe pandemic. Curative drugs specific for COVID-19 are currently lacking. Chloroquine phosphate and its derivative hydroxychloroquine, which have been used in the treatment and prevention of malaria and autoimmune diseases for decades, were found to inhibit SARS-CoV-2 infection with high potency in vitro and have shown clinical and virologic benefits in COVID-19 patients.

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