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Tafenoquine

Guidance for Using Tafenoquine for Prevention and Antirelapse Therapy for Malaria - United States, 2019

November 30, 2019 - 20:08 -- Open Access
Author(s): 
Haston JC, Hwang J, Tan KR.
Reference: 
MMWR Morb Mortal Wkly Rep. 2019 Nov 22;68(46):1062-1068.

This report summarizes the published efficacy and safety evidence for the recommended doses for both indications and provides guidance for the use of tafenoquine in the United States. A more comprehensive review of the literature on tafenoquine along with the biologic rationale for its use has been published elsewhere (10).

Killing of Plasmodium vivax by Primaquine and Tafenoquine

October 30, 2019 - 09:45 -- Open Access
Author(s): 
Miles B. Markus
Reference: 
Trends In Parasitology, Volume 35, ISSUE 11, P857-859, November 01, 2019

Primaquine administration results in H 2O 2 accumulation in bone marrow, where gametocytes and asexual parasites are therefore killed. This finding, by Camarda et al. , supports the theory that the nonperipheral blood origin of recurrent Plasmodium vivax malaria is both hypnozoites (relapse source) and merozoites (recrudescence source), not hypnozoites only.

Medical Condition: 
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