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co-infection

Malaria and helminth co-infections in children living in endemic countries: A systematic review with meta-analysis

February 23, 2021 - 14:05 -- Open Access
Author(s): 
Afolabi MO, Ale BM, Dabira ED, Agbla SC, Bustinduy AL, Ndiaye JLA, Greenwood B
Reference: 
PLoS Negl Trop Dis. 2021 Feb 18;15(2):e0009138

Current knowledge on the burden of, and interactions between malaria and helminth co-infections, as well as the impact of the dual infections on anaemia, remains inconclusive. We have conducted a systematic review with meta-analysis to update current knowledge as a first step towards developing and deploying coordinated approaches to the control and, ultimately, elimination of malaria-helminth co-infections among children living in endemic countries.

Plasmodium cynomolgi Co-infections among Symptomatic Malaria Patients, Thailand

February 2, 2021 - 16:48 -- Open Access
Author(s): 
Putaporntip C, Kuamsab N, Pattanawong U, Yanmanee S, Seethamchai S, Jongwutiwes S
Reference: 
Emerg Infect Dis. 2021 Feb;27(2):590-593

Among 1,180 symptomatic malaria patients, 9 (0.76%) infected with Plasmodium cynomolgi were co-infected with P. vivax (n = 7), P. falciparum (n = 1), or P. vivax and P. knowlesi (n = 1). Patients were from Tak, Chanthaburi, Ubon Ratchathani, Yala, and Narathiwat Provinces, suggesting P. cynomolgi is widespread in this country.

Malaria and intestinal parasite co-infection and its association with anaemia among people living with HIV in Buea, Southwest Cameroon: A community-based retrospective cohort study

January 27, 2021 - 10:45 -- Open Access
Author(s): 
Mekachie Sandie S, Sumbele IUN, Tasah MM, Kimbi HK
Reference: 
PLoS One. 2021 Jan 22;16(1):e0245743

Both malaria and intestinal parasites are endemic in Cameroon, and their co-infection can be of great impact on anaemia among people living with HIV (PLWH). This community-based retrospective cohort study determined the prevalence and association of infections with anaemia in PLWH and HIV-negative individuals in Buea, Cameroon from March to August 2019.

Disrupted Iron Metabolism and Mortality during Co-infection with Malaria and an Intestinal Gram-Negative Extracellular Pathogen

January 14, 2021 - 08:45 -- Open Access
Author(s): 
Dos Santos LI, Torres TA, Diniz SQ, Gonçalves R, Caballero-Flores G, Núñez G, Gazzinelli RT, Maloy KJ, Ribeiro do V Antonelli L
Reference: 
Cell Rep. 2021 Jan 12;34(2):108613

Individuals with malaria exhibit increased morbidity and mortality when infected with Gram-negative (Gr-) bacteria. To explore this experimentally, we performed co-infection of mice with Plasmodium chabaudi and Citrobacter rodentium, an extracellular Gr- bacterial pathogen that infects the large intestine. While single infections are controlled effectively, co-infection results in enhanced virulence that is characterized by prolonged systemic bacterial persistence and high mortality.

Should we care about Plasmodium vivax and HIV co-infection? A systematic review and a cases series from the Brazilian Amazon

January 9, 2021 - 12:17 -- Open Access
Author(s): 
Paola López Del-Tejo, Nadia Cubas-Vega, Fernando Val, et al.
Reference: 
Malaria Journal 2021 20:13, 6 January 2021

Malaria and HIV are two important public health issues. However, evidence on HIV-Plasmodium vivax co-infection (HIV/PvCo) is scarce, with most of the available information related to Plasmodium falciparum on the African continent. It is unclear whether HIV can change the clinical course of vivax malaria and increase the risk of complications. In this study, a systematic review of HIV/PvCo studies was performed, and recent cases from the Brazilian Amazon were included.

Co-infection of malaria and early clearance of SARS-CoV-2 in healthcare workers

December 30, 2020 - 13:39 -- Open Access
Author(s): 
Mahajan NN, Gajbhiye R, Bahirat S, Lokhande PD, Mathe A, Rathi S, Warty N, Mahajan K, Srivastava V, Kuppusamy P, Mohite SC
Reference: 
J Med Virol. 2020 Dec 24

Healthcare workers (HCWs) are at higher risk of contracting SARS‐CoV‐2 infection. Information regarding co‐infection of SARS‐CoV‐2 with vector‐borne diseases (malaria and dengue) is crucial especially for the countries wherein malaria and dengue are endemic. The objective was to study the prevalence, demographic, clinical presentations among HCWs with COVID‐19 and to compare the viral clearance in HCWs with COVID‐19 and co‐infection of malaria and dengue.

Pharmacogenetic considerations in the treatment of co-infections with HIV/AIDS, tuberculosis and malaria in Congolese populations of Central Africa

December 15, 2020 - 14:38 -- Open Access
Author(s): 
Pallerla SR, Assiana DOE, Velavan TP, et al.
Reference: 
Int J Infect Dis. 2020 Dec 9:S1201-9712(20)32532-7

HIV-infection, tuberculosis and malaria are the big three communicable diseases that plague sub-Saharan Africa. If these diseases occur as co-morbidities they require polypharmacy, which may lead to severe drug-drug-gene interactions and variation in adverse drug reactions, but also in treatment outcomes. Polymorphisms in genes encoding drug-metabolizing enzymes are the major cause of these variations, but such polymorphisms may support the prediction of drug efficacy and toxicity. There is little information on allele frequencies of pharmacogenetic variants of enzymes involved in the metabolism of drugs used to treat HIV-infection, TB and malaria in the Republic of Congo (ROC). The aim of this study was therefore to investigate the occurrence and allele frequencies of 32 pharmacogenetic variants localized in absorption distribution, metabolism and excretion (ADME) and non-ADME genes and to compare the frequencies with population data of African and non-African derived from the 1000 Genomes Project.

Prevalence of and risk factors for Plasmodium spp. co-infection with hepatitis B virus: a systematic review and meta-analysis

October 15, 2020 - 08:46 -- Open Access
Author(s): 
Kwuntida Uthaisar Kotepui and Manas Kotepui
Reference: 
Malaria Journal 2020 19:368, 15 October 2020

Plasmodium spp. and hepatitis B virus (HBV) are among the most common infectious diseases in underdeveloped countries. This study aimed to determine the prevalence of Plasmodium spp. and HBV co-infection in people living in endemic areas of both diseases and to assess the risk factors related to this co-infection.

Prevalence of and risk factors for severe malaria caused by Plasmodium and dengue virus co-infection: a systematic review and meta-analysis

September 24, 2020 - 08:09 -- Open Access
Author(s): 
Kotepui M, Kotepui KU, Milanez GJ, Masangkay FR
Reference: 
Infect Dis Poverty. 2020 Sep 22;9(1):134.

Co-infection with both Plasmodium and dengue virus (DENV) infectious species could have serious and fatal outcomes if left undiagnosed and without timely treatment. The present study aimed to determine the pooled prevalence estimate of severe malaria among patients with co-infection, the risk of severe diseases due to co-infection, and to describe the complications of severe malaria and severe dengue among patients with co-infection.

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