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quinoline derivatives

NOT Open Access | Current Pharmaceutical Aspects of Synthetic Quinoline Derivatives

December 16, 2020 - 12:19 -- NOT Open Access
Tabassum R, Ashfaq M, Oku H
Mini Rev Med Chem. 2020 Dec 14

Quinoline derivatives are considered as broad spectrum pharmacological compounds that exhibit wide range of biological activities. Integration of quinoline moiety can improve its physical and chemical properties and also pharmacological behavior. Due to its wide range of pharmaceutical applications it is very popular compound to design new drugs for treatment of multiple diseases like cancer, dengue fever, malaria, tuberculosis, fungal infections, AIDS, Alzheimer's disease and diabetes.

Chloroquine against malaria, cancers and viral diseases

September 23, 2020 - 08:44 -- Open Access
Zhou W, Wang H, Yang Y, Chen ZS, Zou C, Zhang J
Drug Discov Today. 2020 Sep 16:S1359-6446(20)30367-6

Quinoline (QN) derivatives are often used for the prophylaxis and treatment of malaria. Chloroquine (CQ), a protonated, weakly basic drug, exerts its antimalarial effect mainly by increasing pH and accumulating in the food vacuole of the parasites.

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