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Markers of sulfadoxine–pyrimethamine resistance in Eastern Democratic Republic of Congo; implications for malaria chemoprevention

December 30, 2019 - 14:13 -- Open Access
Marit van Lenthe, Renske van der Meulen, Cally Roper, et al.
Malaria Journal 2019 18:430, 18 December 2019

Sulfadoxine–pyrimethamine (SP) is a cornerstone of malaria chemoprophylaxis and is considered for programmes in the Democratic Republic of Congo (DRC). However, SP efficacy is threatened by drug resistance, that is conferred by mutations in the dhfr and dhps genes. The World Health Organization has specified that intermittent preventive treatment for infants (IPTi) with SP should be implemented only if the prevalence of the dhps K540E mutation is under 50%. There are limited current data on the prevalence of resistance-conferring mutations available from Eastern DRC. The current study aimed to address this knowledge gap.

Forest work and its implications for malaria elimination: a qualitative study

December 2, 2019 - 14:50 -- Open Access
Sanann N, Peto TJ, Pell C, et al.
Malaria Journal volume 18, Article number: 376 (2019)

Over the last 20 years, malaria incidence has decreased across the Greater Mekong Sub-region (GMS) and the emergence of artemisinin resistance has stimulated efforts to accelerate regional elimination. In the GMS, the malaria transmission is focused increasingly in forested zones. This article describes forest-going activities and examines forest workers’ attitudes to and experiences of malaria prevention and control in north-eastern Cambodia.

Farmers’ pesticide usage practices in the malaria endemic region of North-Western Tanzania: implications to the control of malaria vectors

November 8, 2019 - 16:53 -- Open Access
Anitha Philbert, Sylvester Leonard Lyantagaye & Gamba Nkwengulila
BMC Public Health volume 19, Article number: 1456 (2019)

Pesticides remain the mainstay for the control of agricultural pests and disease vectors. However, their indiscriminate use in agriculture has led to development of resistance to both crop pests and disease vectors. 


NOT Open Access | Kinetic Driver of Antibacterial Drugs against Plasmodium falciparum and Implications for Clinical Dosing

October 28, 2019 - 16:27 -- NOT Open Access
Emily Caton, Elizabeth Nenortas, Rahul P. Bakshi and Theresa A. Shapiro
Antimicrob. Agents Chemother. November 2019 63:e00416-19

Antibacterial drugs are an important component of malaria therapy. We studied the interactions of clindamycin, tetracycline, chloramphenicol, and ciprofloxacin against Plasmodium falciparum under static and dynamic conditions.

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