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antimalarial pyrazolo pyridines

NOT Open Access | Synthesis and structure-activity relationship of dual-stage antimalarial pyrazolo[3,4-b]pyridines

September 22, 2020 - 10:29 -- NOT Open Access
Author(s): 
Eagon S, Hammill JT, Guy RK, et al.
Reference: 
J Med Chem. 2020 Sep 18

Malaria remains one of the most deadly infectious diseases, causing hundreds of thousands of deaths each year, primarily in young children and pregnant mothers. Here we report the discovery and derivatization of a series of pyrazolo[3,4-b]pyridines targeting Plasmodium falciparum, the deadliest species of the malaria parasite.

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