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RTS S/AS01(E) vaccine

Seasonal malaria vaccination: protocol of a phase 3 trial of seasonal vaccination with the RTS,S/AS01(E) vaccine, seasonal malaria chemoprevention and the combination of vaccination and chemoprevention

September 16, 2020 - 13:13 -- Open Access
Chandramohan D, Dicko A, Greenwood B, et al.
BMJ Open. 2020 Sep 15;10(9):e035433

Seasonal malaria chemoprevention (SMC), with sulphadoxine-pyrimethamine plus amodiaquine (SP+AQ) is effective but does not provide complete protection against clinical malaria. The RTS,S/AS01E malaria vaccine provides a high level of protection shortly after vaccination, but this wanes rapidly. Such a vaccine could be an alternative or additive to SMC. This trial aims to determine whether seasonal vaccination with RTS,S/AS01E vaccine could be an alternative to SMC and whether a combination of the two interventions would provide added benefits.

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