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Caspase-8 mediates inflammation and disease in rodent malaria

September 16, 2020 - 13:03 -- Open Access
Author(s): 
Pereira LMN, Assis PA, Gazzinelli RT, et al.
Reference: 
Nat Commun. 2020 Sep 14;11(1):4596

Earlier studies indicate that either the canonical or non-canonical pathways of inflammasome activation have a limited role on malaria pathogenesis. Here, we report that caspase-8 is a central mediator of systemic inflammation, septic shock in the Plasmodium chabaudi-infected mice and the P. berghei-induced experimental cerebral malaria (ECM).

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