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Evaluation of two sexual-stage antigens as bivalent transmission-blocking vaccines in rodent malaria

May 12, 2021 - 09:30 -- Open Access
Author(s): 
Yang F, Liu F, Yu X, Zheng W, Wu Y, Qiu Y, Jin Y, Cui L, Cao Y
Reference: 
Parasit Vectors. 2021 May 7;14(1):241

Transmission-blocking vaccine (TBV) is a promising strategy for malaria elimination. It is hypothesized that mixing or fusing two antigens targeting different stages of sexual development may provide higher transmission-blocking activity than these antigens used individually.

Plasmodium vinckei genomes provide insights into the pan-genome and evolution of rodent malaria parasites

April 29, 2021 - 08:08 -- Open Access
Author(s): 
Ramaprasad A, Klaus S, Douvropoulou O, Culleton R, Pain A
Reference: 
BMC Biol. 2021 Apr 23;19(1):69

Rodent malaria parasites (RMPs) serve as tractable tools to study malaria parasite biology and host-parasite-vector interactions. Among the four RMPs originally collected from wild thicket rats in sub-Saharan Central Africa and adapted to laboratory mice, Plasmodium vinckei is the most geographically widespread with isolates collected from five separate locations. However, there is a lack of extensive phenotype and genotype data associated with this species, thus hindering its use in experimental studies.

Comparative intravital imaging of human and rodent malaria sporozoites reveals the skin is not a species-specific barrier

March 24, 2021 - 14:05 -- Open Access
Author(s): 
Hopp CS, Kanatani S, Archer NK, Miller RJ, Liu H, Chiou KK, Miller LS, Sinnis P
Reference: 
EMBO Mol Med. 2021 Mar 22:e11796

Malaria infection starts with the injection of Plasmodium sporozoites into the host's skin. Sporozoites are motile and move in the skin to find and enter blood vessels to be carried to the liver. Here, we present the first characterization of P. falciparum sporozoites in vivo, analyzing their motility in mouse skin and human skin xenografts and comparing their motility to two rodent malaria species.

NOT Open Access | Malaria-induced Alterations of Drug Kinetics and Metabolism in Rodents and Humans

January 6, 2021 - 12:46 -- NOT Open Access
Author(s): 
De-Oliveira ACAX, Paumgartten FJR
Reference: 
Curr Drug Metab. 2021 Jan 1

Infections and inflammation lead to a downregulation of drug metabolism and kinetics in experimental animals. These changes in the expression and activities of drug-metabolizing enzymes may affect the effectiveness and safety of pharmacotherapy of infections and inflammatory conditions.

Definition of constitutive and stage-enriched promoters in the rodent malaria parasite, Plasmodium yoelii

November 24, 2020 - 14:54 -- Open Access
Author(s): 
Laura M. Bowman, Logan E. Finger, Kevin J. Hart and Scott E. Lindner
Reference: 
Malaria Journal 2020 19:424, 23 November 2020

Well-defined promoters are essential elements for genetic studies in all organisms, and enable controlled expression of endogenous genes, transgene expression, and gene editing. Despite this, there is a paucity of defined promoters for the rodent-infectious malaria parasites. This is especially true for Plasmodium yoelii, which is often used to study the mosquito and liver stages of malarial infection, as well as host immune responses to infection.

Caspase-8 mediates inflammation and disease in rodent malaria

September 16, 2020 - 13:03 -- Open Access
Author(s): 
Pereira LMN, Assis PA, Gazzinelli RT, et al.
Reference: 
Nat Commun. 2020 Sep 14;11(1):4596

Earlier studies indicate that either the canonical or non-canonical pathways of inflammasome activation have a limited role on malaria pathogenesis. Here, we report that caspase-8 is a central mediator of systemic inflammation, septic shock in the Plasmodium chabaudi-infected mice and the P. berghei-induced experimental cerebral malaria (ECM).

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