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IFN-γ

Contributions of IFN-γ and granulysin to the clearance of Plasmodium yoelii blood stage

September 15, 2020 - 10:59 -- Open Access
Author(s): 
Hojo-Souza NS, de Azevedo PO, de Castro JT, Teixeira-Carvalho A, Lieberman J, Junqueira C, Gazzinelli RT
Reference: 
PLoS Pathog. 2020 Sep 10;16(9):e1008840

P. vivax-infected Retics (iRetics) express human leukocyte antigen class I (HLA-I), are recognized by CD8+ T cells and killed by granulysin (GNLY) and granzymes. However, how Plasmodium infection induces MHC-I expression on Retics is unknown. In addition, whether GNLY helps control Plasmodium infection in vivo has not been studied. Here, we examine these questions using rodent infection with the P. yoelii 17XNL strain, which has tropism for Retics.

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