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TRAIL

Artemisinin Derivatives Stimulate DR5-Specific TRAIL-Induced Apoptosis by Regulating Wildtype P53

September 12, 2020 - 14:54 -- Open Access
Author(s): 
Zhou X, Zijlstra SN, Soto-Gamez A, Setroikromo R, Quax WJ
Reference: 
Cancers (Basel). 2020 Sep 4;12(9):E2514

Artemisinin derivatives, widely known as commercial anti-malaria drugs, may also have huge potential in treating cancer cells. It has been reported that artemisinin derivatives can overcome resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in liver and cervical cancer cells. In our study, we demonstrated that artesunate (ATS) and dihydroartemisinin (DHA) are more efficient in killing colon cancer cells compared to artemisinin (ART).

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