Plasmodium falciparum has a complex life cycle that involves interaction with multiple tissues inside the human and mosquito hosts. Identification of essential genes at all different stages of the P. falciparum life cycle is urgently required for clinical development of tools for malaria control and eradication.
Plasmodium falciparum life cycle
mBio September/October 2019 10:e01170-19
PLoS Genet 15(10): e1008453
Determining the genetic basis of fitness is central to understanding evolution and transmission of microbial pathogens.