NOT Open Access | The Effect of Gastric pH on the Pharmacokinetics-Pharmacodynamics of Naphthoquine in Rodents, as well as in Human Predicted Using a PBPK Model
Fixed-dose combination of artemisinin and naphthoquine (NQ) is a new artemisinin-based combination therapy for the treatment of uncomplicated Plasmodium falciparum. NQ absorption has been reported to be affected by food in human.