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NOT Open Access | Targeting and inhibiting Plasmodium falciparum using ultra-small gold nanoparticles

September 5, 2020 - 14:36 -- NOT Open Access
Varela-Aramburu S, Ghosh C, Goerdeler F, Priegue P, Moscovitz O, Seeberger PH
ACS Appl Mater Interfaces. 2020 Sep 2

Malaria, a mosquito-borne disease caused by the Plasmodium species, claims more than 400,000 lives globally each year. Increasing drug resistance of the parasite renders the development of new anti-malaria drugs necessary. Alternatively, better delivery systems for already marketed drugs could help to solve the resistance problem. Herein, we report glucose-based ultra-small gold nanoparticles (Glc-NCs) that bind to cysteine-rich domains of Plasmodium falciparum surface proteins.

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