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JNK signaling

JNK signaling regulates oviposition in the malaria vector Anopheles gambiae

September 2, 2020 - 11:52 -- Open Access
Peirce MJ, Mitchell SN, Kakani EG, Scarpelli P, South A, Shaw WR, Werling KL, Gabrieli P, Marcenac P, Bordoni M, Talesa V, Catteruccia F
Sci Rep. 2020 Sep 1;10(1):14344

The reproductive fitness of the Anopheles gambiae mosquito represents a promising target to prevent malaria transmission. The ecdysteroid hormone 20-hydroxyecdysone (20E), transferred from male to female during copulation, is key to An. gambiae reproductive success as it licenses females to oviposit eggs developed after blood feeding. Here we show that 20E-triggered oviposition in these mosquitoes is regulated by the stress- and immune-responsive c-Jun N-terminal kinase (JNK).

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