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antimalarial chemotype

NOT Open Access | Half-Sandwich Cyclopentadienylruthenium(II) Complexes: A New Antimalarial Chemotype

August 25, 2020 - 15:34 -- NOT Open Access
Author(s): 
Milheiro SA, Gonçalves J, Moreira R, et al.
Reference: 
Inorg Chem. 2020 Aug 24

A small library of "half-sandwich" cyclopentadienylruthenium(II) compounds of the general formula [(η5-C5R5)Ru(PPh3)(N-N)][PF6], a scaffold hitherto absent from the toolbox of antiplasmodials, was screened for activity against the blood stage of CQ-sensitive 3D7-GFP, CQ-resistant Dd2, and artemisinin-resistant IPC5202 Plasmodium falciparum strains and the liver stage of Plasmodium berghei.

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