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NOT Open Access | Therapeutic Efficacy of Artemisinin-Based Combination Therapies in Democratic Republic of the Congo and Investigation of Molecular Markers of Antimalarial Resistance

September 8, 2021 - 17:15 -- NOT Open Access
Moriarty LF, Nkoli PM, Kahunu GM, et al.
Am J Trop Med Hyg. 2021 Sep 7:tpmd210214

Routine assessment of the efficacy of artemisinin-based combination therapies (ACTs) is critical for the early detection of antimalarial resistance. We evaluated the efficacy of ACTs recommended for treatment of uncomplicated malaria in five sites in Democratic Republic of the Congo (DRC): artemether-lumefantrine (AL), artesunate-amodiaquine (ASAQ), and dihydroartemisinin-piperaquine (DP). Children aged 6-59 months with confirmed Plasmodium falciparum malaria were treated with one of the three ACTs and monitored.

Knowledge of Antimalarials and Health Seeking Behaviour of Households in Case of Suspected Malaria in Democratic Republic of the Congo

September 1, 2021 - 17:18 -- Open Access
Ntamabyaliro NY, Burri C, Tona GL, et al.
Trop Med Infect Dis. 2021 Aug 26;6(3):157

The Democratic Republic of the Congo (DRC) is heavily affected by malaria despite availability of effective treatments. Ignorance and unrecommended behaviour toward a suspected malaria case in households may contribute to this problem.

The epidemiology of Plasmodium vivax among adults in the Democratic Republic of the Congo

July 14, 2021 - 10:15 -- Open Access
Brazeau NF, Mitchell CL, Juliano JJ, et al.
Nat Commun. 2021 Jul 7;12(1):4169

Reports of P. vivax infections among Duffy-negative hosts have accumulated throughout sub-Saharan Africa. Despite this growing body of evidence, no nationally representative epidemiological surveys of P. vivax in sub-Saharan Africa have been performed. To overcome this gap in knowledge, we screened over 17,000 adults in the Democratic Republic of the Congo (DRC) for P. vivax using samples from the 2013-2014 Demographic Health Survey.

Care-seeking behaviour and socio-economic burden associated with uncomplicated malaria in the Democratic Republic of Congo

June 16, 2021 - 12:32 -- Open Access
Nadine Kalenda Kayiba, Doudou Malekita Yobi, Niko Speybroeck, et al.
Malaria Journal 2021 20:260, 9 June 2021

This study aimed to estimate the socio-economic costs of uncomplicated malaria and to explore health care-seeking behaviours that are likely to influence these costs in the Democratic Republic of Congo (DRC), a country ranked worldwide as the second most affected by malaria.

Associating the scale-up of insecticide-treated nets and use with the decline in all-cause child mortality in the Democratic Republic of Congo from 2005 to 2014

June 5, 2021 - 06:23 -- Open Access
Johanna Karemere, Ismael G. Nana, Andrew Andrada, Olivier Kakesa, Eric Mukomena Sompwe, Joris Likwela Losimba, Jacques Emina, Aboubacar Sadou, Michael Humes and Yazoumé Yé
Malaria Journal 2021 20:241, 29 May 2021

To reduce the malaria burden and improve the socioeconomic status of its citizens, the Democratic Republic of Congo scaled up key malaria control interventions, especially insecticide-treated nets (ITNs), between 2005 and 2014. Since then, the effects of these interventions on malaria mortality and morbidity have not been assessed. This study aimed to measure the impact of the National Malaria Control Programme’s efforts and to inform future control strategies.

NOT Open Access | Individual, household and neighborhood risk factors for malaria in the Democratic Republic of the Congo support new approaches to programmatic intervention

May 26, 2021 - 14:32 -- NOT Open Access
Carrel M, Kim S, Parr JB, et al.
Health Place. 2021 May 18;70:102581

The Democratic Republic of the Congo (DRC) remains one of the countries most impacted by malaria despite decades of control efforts, including multiple mass insecticide treated net (ITN) distribution campaigns. The multi-scalar and complex nature of malaria necessitates an understanding of malaria risk factors over time and at multiple levels (e.g., individual, household, community). Surveillance of households in both rural and urban settings over time, coupled with detailed behavioral and geographic data, enables the detection of seasonal trends in malaria prevalence and malaria-associated behaviors as well as the assessment of how the local environments within and surrounding an individual's household impact malaria outcomes.

Profiling malaria infection among under-five children in the Democratic Republic of Congo

May 12, 2021 - 12:26 -- Open Access
Emina JBO, Doctor HV, Yé Y
PLoS One. 2021 May 6;16(5):e0250550

In 2018, Malaria accounted for 38% of the overall morbidity and 36% of the overall mortality in the Democratic Republic of Congo (DRC). This study aimed to identify malaria socioeconomic predictors among children aged 6–59 months in DRC and to describe a socioeconomic profile of the most-at-risk children aged 6–59 months for malaria infection.

Analysis of false-negative rapid diagnostic tests for symptomatic malaria in the Democratic Republic of the Congo

March 24, 2021 - 15:08 -- Open Access
Parr JB, Kieto E, Kalonji A, et al.
Sci Rep. 2021 Mar 22;11(1):6495

The majority of Plasmodium falciparum malaria diagnoses in Africa are made using rapid diagnostic tests (RDTs) that detect histidine-rich protein 2. Increasing reports of false-negative RDT results due to parasites with deletions of the pfhrp2 and/or pfhrp3 genes (pfhrp2/3) raise concern about existing malaria diagnostic strategies. We previously identified pfhrp2-negative parasites among asymptomatic children in the Democratic Republic of the Congo (DRC), but their impact on diagnosis of symptomatic malaria is unknown.

NOT Open Access | What is the burden of malaria in the DRC

October 20, 2020 - 16:09 -- NOT Open Access
Deutsch-Feldman M, Parr JB, Keeler C, Brazeau NF, Goel V, Emch M, Edwards JK, Kashamuka M, Tshefu AK, Meshnick SR
J Infect Dis. 2020 Oct 15:jiaa650

Despite evidence that older children and adolescents bear the highest burden of malaria, large malaria surveys focus on younger children.

How useful are malaria risk maps at the country level? Perceptions of decision-makers in Kenya, Malawi and the Democratic Republic of Congo

October 6, 2020 - 12:47 -- Open Access
Ludovica Ghilardi, George Okello, Jayne Webster, et al.
Malaria Journal 2020 19:353, 2 October 2020

Declining malaria prevalence and pressure on external funding have increased the need for efficiency in malaria control in sub-Saharan Africa (SSA). Modelled Plasmodium falciparum parasite rate (PfPR) maps are increasingly becoming available and provide information on the epidemiological situation of countries. However, how these maps are understood or used for national malaria planning is rarely explored. In this study, the practices and perceptions of national decision-makers on the utility of malaria risk maps, showing prevalence of parasitaemia or incidence of illness, was investigated.


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