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plasmodium viva

Ribosomal and non-ribosomal PCR targets for the detection of low-density and mixed malaria infections

May 3, 2019 - 17:30 -- Open Access
Lara Cotta Amaral, Daniela Rocha Robortella, Luzia Helena Carvalho, et al.
Malaria Journal 2019 18:154, 30 April 2019

The unexpected high proportion of submicroscopic malaria infections in areas with low transmission intensity challenges the control and elimination of malaria in the Americas. The current PCR-based assays present limitations as most protocols still rely on amplification of few-copies target gene. Here, the hypothesis was that amplification of different plasmodial targets—ribosomal (18S rRNA) and non-ribosomal multi-copy sequences (Pvr47 for Plasmodium vivax and Pfr364 for Plasmodium falciparum)—could increase the chances of detecting submicroscopic malaria infection.

Safety of primaquine in infants with Plasmodium vivax malaria in Papua, Indonesia

April 4, 2019 - 15:51 -- Open Access
Agus Setyadi, Eggi Arguni, Jeanne R. Poespoprodjo, et al.
Malaria Journal 2019 18:111, 2 April 2019

Severe clinical outcomes amongst infants treated with primaquine in Papua were rare.

Medical Treatment: 

Plasmodium vivax Pv12 B-cell epitopes and HLA-DRβ1*-dependent T-cell epitopes in vitro antigenicity

September 25, 2018 - 14:56 -- Open Access
Yoelis Yepes-Pérez, Carolina López, Carlos Fernando Suárez, Manuel Alfonso Patarroyo
PLoS ONE 13(9): e0203715

Malaria is an infectious disease caused by parasites from the genus Plasmodium (P. falciparum and P. vivax are responsible for 90% of all clinical cases); it is widely distributed throughout the world’s tropical and subtropical regions.

Analysis of polymorphisms in the circumsporozoite protein gene of Plasmodium vivax isolates from Henan Province, China

March 6, 2018 - 15:22 -- Open Access
Ying Liu, Rui-min Zhou, Bian-li Xu, et al.
Malaria Journal 2018 17:103, 5 March 2018

Recent P. vivax populations in Henan province showed some degree of genetic diversity in csp, with 8 sub-types among 32 samples.

Efficacy and safety of artemisinin-based combination therapy and chloroquine with concomitant primaquine to treat Plasmodium vivax malaria in Brazil: an open label randomized clinical trial

January 24, 2018 - 13:30 -- Open Access
André Daher, Dhelio Pereira, David G. Lalloo, et al.
Malaria Journal 2018 17:45, 24 January 2018

This study demonstrated the efficacy and safety of all three regimens that were tested with 42-day cure rates that meet World Health Organization criteria.

Medical Treatment: 

Primaquine ineligibility in anti-relapse therapy of Plasmodium vivax malaria: the problem of G6PD deficiency and cytochrome P-450 2D6 polymorphisms

January 23, 2018 - 16:04 -- Open Access
J. Kevin Baird, Katherine E. Battle and Rosalind E. Howes
Malaria Journal 2018 17:42, 22 January 2018

The hypnozoite reservoir of Plasmodium vivax represents both the greatest obstacle and opportunity for ultimately eradicating this species.

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